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Passive immunisation against varicella infections
Adult: In individuals who are at high risk of severe varicella infection and complications and have no antibodies to varicella-zoster virus (VZV) and who have significant exposure to varicella or herpes zoster: >40 kg: 625 IU, administer as a single inj as soon as possible (ideally within 96 hours) and within 10 days following exposure to VZV. Divide dose and inject in ≥2 sites, depending on patient size (Max: 3 mL per inj site). Alternatively, ≥15 IU/kg or 1,000 mg given as soon as possible (ideally within 3 days) and within 10 days following exposure; if >5 mL is required, administer in divided doses at different sites. A 2nd full dose may be given if an additional exposure to varicella occurs >3 weeks after the initial dose. Dosage recommendations may vary among countries or individual products (refer to specific product guideline).
Child: Dosing based on weight: ≤2 kg: 62.5 IU; 2.1-10 kg: 125 IU; 10.1-20 kg: 250 IU; 20.1-30 kg: 375 IU; 30.1-40 kg: 500 IU; >40 kg: 625 IU. Administer as a single inj as soon as possible (ideally within 96 hours) and within 10 days following exposure to VZV. Divide dose and inject in ≥2 sites, depending on patient size (Max: 3 mL per inj site). Alternative dosing recommendations: ≥15 IU/kg given as soon as possible (ideally within 3 days) and within 10 days following exposure. Dosing based on age: 0-5 years 250 mg; 6-10 years 500 mg; 11-14 years 750 mg; ≥15 years 1,000 mg. Dose to be given as soon as possible (ideally within 3 days) and within 10 days following exposure; if >2 mL is required, administer in divided doses at different sites. A 2nd full dose may be given if an additional exposure to varicella occurs >3 weeks after the initial dose. Dosage recommendations may vary among countries or individual products (refer to specific product guideline).
Child: Dosing based on weight: ≤2 kg: 62.5 IU; 2.1-10 kg: 125 IU; 10.1-20 kg: 250 IU; 20.1-30 kg: 375 IU; 30.1-40 kg: 500 IU; >40 kg: 625 IU. Administer as a single inj as soon as possible (ideally within 96 hours) and within 10 days following exposure to VZV. Divide dose and inject in ≥2 sites, depending on patient size (Max: 3 mL per inj site). Alternative dosing recommendations: ≥15 IU/kg given as soon as possible (ideally within 3 days) and within 10 days following exposure. Dosing based on age: 0-5 years 250 mg; 6-10 years 500 mg; 11-14 years 750 mg; ≥15 years 1,000 mg. Dose to be given as soon as possible (ideally within 3 days) and within 10 days following exposure; if >2 mL is required, administer in divided doses at different sites. A 2nd full dose may be given if an additional exposure to varicella occurs >3 weeks after the initial dose. Dosage recommendations may vary among countries or individual products (refer to specific product guideline).
